Journal
ENDOCRINOLOGY
Volume 158, Issue 5, Pages 1074-1084Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2017-00218
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Funding
- Swiss National Science Foundation [31003A_166700/1]
- Novartis Consumer Health Foundation
- Fondation Romande pour la Recherche sur le Diabete
- European Foundation
- Fondation privee des Hopitaux Universitaires de Geneve
- Bo and Kerstin Hjelt Foundation
- Olga Mayenfisch Foundation
- Swiss National Science Foundation (SNF) [31003A_166700] Funding Source: Swiss National Science Foundation (SNF)
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Most organisms, including humans, have developed an intrinsic system of circadian oscillators, allowing the anticipation of events related to the rotation of Earth around its own axis. The mammalian circadian timing system orchestrates nearly all aspects of physiology and behavior. Together with systemic signals, emanating from the central clock that resides in the hypothalamus, peripheral oscillators orchestrate tissue-specific fluctuations in gene expression, protein synthesis, and posttranslational modifications, driving overt rhythms in physiology and behavior. There is increasing evidence on the essential roles of the peripheral oscillators, operative in metabolically active organs in the regulation of body glucose homeostasis. Here, we review some recent findings on the molecular and cellular makeup of the circadian timing system and its implications in the temporal coordination of metabolism in health and disease.
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