Journal
ENDOCRINE-RELATED CANCER
Volume 24, Issue 3, Pages C1-C4Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-16-0496
Keywords
acromegaly; pathology; radiology; biomarkers; pituitary tumors
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Acromegaly has traditionally been regarded as a monomorphous disorder resulting from a benign pituitary adenoma. Increasing evidence, however, is highlighting that this disorder is associated with a spectrum of morphologically distinct pituitary tumors with variable clinical, biochemical and radiologic features and differing therapeutic outcomes that are attributed to different genetic and epigenetic changes. These data underscore the need for developing a more refined clinicopathological risk stratification system and implementing personalized targeted therapeutic approaches.
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