Related references
Note: Only part of the references are listed.Designing Irreversible InhibitorsWorth the Effort?
Concepcion Gonzalez-Bello
CHEMMEDCHEM (2016)
Recent progress on third generation covalent EGFR inhibitors
Hengmiao Cheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles
Ana B. Bueno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Discovery of 1-{(3R,4R)-3[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Hengmiao Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State
Matthew P. Patricelli et al.
CANCER DISCOVERY (2016)
High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow
Iain D. G. Campuzano et al.
JOURNAL OF BIOMOLECULAR SCREENING (2016)
An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations
Petr Kuzmic et al.
ANALYTICAL BIOCHEMISTRY (2015)
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay
Ikuo Miyahisa et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
Renato A. Bauer
DRUG DISCOVERY TODAY (2015)
PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS
Jayme L. Dahlin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
An Aggregation Advisor for Ligand Discovery
John J. Irwin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Prolonged and tunable residence time using reversible covalent kinase inhibitors
J. Michael Bradshaw et al.
NATURE CHEMICAL BIOLOGY (2015)
The promise and peril of chemical probes
Cheryl H. Arrowsmith et al.
NATURE CHEMICAL BIOLOGY (2015)
Applying thermodynamic profiling in lead finding and optimization
Gerhard Klebe
NATURE REVIEWS DRUG DISCOVERY (2015)
Drug discovery considerations in the development of covalent inhibitors
Robert Mah et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Cancer epigenetics drug discovery and development: the challenge of hitting the mark
Robert M. Campbell et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Mark E. Flanagan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases
Stefan G. Kathman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments
Christian Joest et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Chemical con artists foil drug discovery
Jonathan Baell et al.
NATURE (2014)
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
Bryan R. Lannine et al.
NATURE CHEMICAL BIOLOGY (2014)
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Phillip A. Schwartz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
In vitro studies on the reaction rates of acrylamide with the key body-fluid thiols L-cysteine, glutathione, and captopril
Grace-Anne Bent et al.
TOXICOLOGY RESEARCH (2014)
Diverse Functional Roles of Reactive Cysteines
Nicholas J. Pace et al.
ACS CHEMICAL BIOLOGY (2013)
What is the total number of protein molecules per cell volume? A call to rethink some published values
Ron Milo
BIOESSAYS (2013)
Learning from our mistakes: The 'unknown knowns' in fragment screening
Ben J. Davis et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Modification and Functional Inhibition of Regulator of G-Protein Signaling 4 (RGS4) by 4-Hydroxy-2-nonenal
C. Aaron Monroy et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2013)
Developing Irreversible Inhibitors of the Protein Kinase Cysteinome
Qingsong Liu et al.
CHEMISTRY & BIOLOGY (2013)
Redox regulation of protein kinases
Thu H. Truong et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)
Redox regulation of protein kinases
Aoife Corcoran et al.
FEBS JOURNAL (2013)
Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
Ranjana H. Advani et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Daniel Martinez Molina et al.
SCIENCE (2013)
High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe
Megan M. McCallum et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Kinetic Template-Guided Tethering of Fragments
Rebecca H. Nonoo et al.
CHEMMEDCHEM (2012)
Drug discovery for a new generation of covalent drugs
Amit S. Kalgutkar et al.
EXPERT OPINION ON DRUG DISCOVERY (2012)
Discovery and Structure-Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington's Disease
Michael E. Prime et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay
Christoph W. Zapf et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Candice E. Paulsen et al.
NATURE CHEMICAL BIOLOGY (2012)
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Iana M. Serafimova et al.
NATURE CHEMICAL BIOLOGY (2012)
On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53
Michal Bista et al.
PLOS ONE (2012)
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia
Arny B. Dounay et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents-real hits or promiscuous artifacts?
Paul A. Johnston
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
Alfred Zimmerlin et al.
DRUG METABOLISM AND DISPOSITION (2011)
A Refined Cytochrome P540 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors
Ping Li et al.
DRUG METABOLISM AND DISPOSITION (2011)
Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds
Daniel I. Perez et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
The resurgence of covalent drugs
Juswinder Singh et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
SnapShot: Key Numbers in Biology
Uri Moran et al.
CELL (2010)
Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance
Sabine Klueter et al.
CHEMBIOCHEM (2010)
Inhibition of CYP3A by Erythromycin: In Vitro-In Vivo Correlation in Rats
Xin Zhang et al.
DRUG METABOLISM AND DISPOSITION (2010)
Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin
Sara K. Quinney et al.
DRUG METABOLISM AND DISPOSITION (2010)
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
Douglas S. Johnson et al.
FUTURE MEDICINAL CHEMISTRY (2010)
Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease
Ajit Jadhav et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Quantitative reactivity profiling predicts functional cysteines in proteomes
Eranthie Weerapana et al.
NATURE (2010)
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Lee A. Honigberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4
Howard J. Burt et al.
XENOBIOTICA (2010)
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
Douglas S. Johnson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic Electrophiles-Application to α,β-Unsaturated Ketones, Acrylates, and Propiolates
Alexander Boehme et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Immune-Mediated Adverse Drug Reactions
Jack Uetrecht
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
Kay Ahn et al.
CHEMISTRY & BIOLOGY (2009)
Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
Xin Zhang et al.
DRUG METABOLISM AND DISPOSITION (2009)
Semiphysiologically Based Pharmacokinetic Models for the Inhibition of Midazolam Clearance by Diltiazem and Its Major Metabolite
Xin Zhang et al.
DRUG METABOLISM AND DISPOSITION (2009)
A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
Shintaro Nakayama et al.
DRUG METABOLISM AND DISPOSITION (2009)
Covalent Modifiers: An Orthogonal Approach to Drug Design
Michele H. Potashman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC
Mary K. Doherty et al.
JOURNAL OF PROTEOME RESEARCH (2009)
A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes
Aaron T. Wright et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design
E. S. Perloff et al.
XENOBIOTICA (2009)
Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values
Ben-Fillippo Krippendorff et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
A Novel Class of Small Molecule Inhibitors of Hsp90
Fang Yi et al.
ACS CHEMICAL BIOLOGY (2008)
Timing and dynamics of single cell gene expression in the arabinose utilization system
Judith A. Megerle et al.
BIOPHYSICAL JOURNAL (2008)
Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
Girish Rachakonda et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Covalent inhibitors of human monoacylglycerol lipase: Ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis
Nikolai Zvonok et al.
CHEMISTRY & BIOLOGY (2008)
Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals
Craig Lammert et al.
HEPATOLOGY (2008)
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity
Kyunghye Ahn et al.
BIOCHEMISTRY (2007)
High-resolution timing of cell cycle-regulated gene expression
Maga Rowicka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A simple assay for detection of small-molecule redox activity
Leng A. Lor et al.
JOURNAL OF BIOMOLECULAR SCREENING (2007)
Thermodynamic benchmark study using Biacore technology
Iva Navratilova et al.
ANALYTICAL BIOCHEMISTRY (2007)
Activation mechanism and steady state kinetics of Bruton's tyrosine kinase
Marie Dinh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Higher-throughput, label-free, real-time molecular interaction analysis
Rebecca L. Rich et al.
ANALYTICAL BIOCHEMISTRY (2007)
Mechanism-based inactivation of human cytochrome P450 enzymes and the prediction of drug-drug interactions
R. Scott Obach et al.
DRUG METABOLISM AND DISPOSITION (2007)
Activity-based probes for proteomic profiling of histone deacetylase complexes
Cleo M. Salisbury et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Functional interrogation of the kinome using nucleotide acyl phosphates
Matthew P. Patricelli et al.
BIOCHEMISTRY (2007)
Acrylamide in cereal and cereal products: A review on progress in level reduction
E. J. M. Konings et al.
FOOD ADDITIVES AND CONTAMINANTS (2007)
Acrylamide in coffee: Review of progress in analysis, formation and level reduction
Helmut Guenther et al.
FOOD ADDITIVES AND CONTAMINANTS (2007)
Acrylamide in fried and roasted potato products: A review on progress in mitigation
R. J. Foot et al.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2007)
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
Zhengying Pan et al.
CHEMMEDCHEM (2007)
Toxicophores: Investigations in drug safety
Dominic P. Williams
TOXICOLOGY (2006)
Screening in a spirit haunted world
Brian K. Shoichet
DRUG DISCOVERY TODAY (2006)
A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation
F Ghanbari et al.
CURRENT DRUG METABOLISM (2006)
Biochemical mechanisms of new molecular entities (NMEs) approved by United States FDA during 2001-2004: Mechanisms leading to optimal efficacy and safety
David C. Swinney
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Coupling phosphoryl transfer and substrate interactions in protein kinases
SA Lieser et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis
A Atkinson et al.
DRUG METABOLISM AND DISPOSITION (2005)
Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes
HK Lim et al.
DRUG METABOLISM AND DISPOSITION (2005)
Features of selective kinase inhibitors
ZA Knight et al.
CHEMISTRY & BIOLOGY (2005)
Elucidating mechanisms of drug-induced toxicity
DC Liebler et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597):: Effects on anandamide and oleoylethanolamide deactivation
D Fegley et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition
SA Lieser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Protein-reactive natural products
C Drahl et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Reactions of acrylamide with glutathione and serum albumin
GC Tong et al.
TOXICOLOGY LETTERS (2004)
Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)
A Tjernberg et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites
YH Wang et al.
DRUG METABOLISM AND DISPOSITION (2004)
Activity-based probes for the proteomic profiling of metalloproteases
A Saghatelian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Drug-protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
DC Evans et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity
AH Lichtman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Activity-based probes for protein tyrosine phosphatases
S Kumar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Global analysis of protein expression in yeast
S Ghaemmaghami et al.
NATURE (2003)
Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)
L Wohlbold et al.
BLOOD (2003)
The kinetics of binding to p38 MAP kinase by analogues of BIRB 796
J Regan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
KR Guertin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Mechanistic considerations in high-throughput screening
RA Copeland
ANALYTICAL BIOCHEMISTRY (2003)
Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase
A Lewandowicz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes
K Ito et al.
DRUG METABOLISM AND DISPOSITION (2003)
Both 5-Arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-Thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis Factor-α antagonists
ME Voss et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
SL McGovern et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
High-density miniaturized thermal shift assays as a general strategy for drug discovery
MW Pantoliano et al.
JOURNAL OF BIOMOLECULAR SCREENING (2001)
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α
PH Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A systematic review of the associations between dose regimens and medication compliance
AJ Claxton et al.
CLINICAL THERAPEUTICS (2001)
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
YM Li et al.
NATURE (2000)
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
M Bogyo et al.
CHEMISTRY & BIOLOGY (2000)