Journal
SLAS DISCOVERY
Volume 22, Issue 2, Pages 187-195Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1087057116664029
Keywords
immune thrombocytopenia; gene expression profile; pathway prediction; cytokine
Funding
- Scientific Research Program of Science and Technology Commission of Shanghai Municipality [12411952406]
- Scientific Research Program of Shanghai Municipal Commission of Healthy and Family Planning [201540178]
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In the present study, we sought to define genes associated with immune thrombocytopenia (ITP). Microarray analysis revealed that of 1002 genes associated with ITP, 309 genes had downregulated expression and 693 genes had upregulated expression in patients with ITP. Gene set enrichment analysis revealed that 11 pathways were positively correlated to ITP, such as type I diabetes mellitus, intestinal immune network for IgA production, and oxidative phosphorylation. The messenger RNA expression levels of the indicated genes, including HLA-DRB5, IGHV3-66, IFI27, FAM212A, PLD5, tumor necrosis factor (TNF)-alpha, interferon-gamma, interleukin (IL)-1 beta, and IL-4, were significantly increased in patients with ITP compared with healthy humans, while MMP8, SLC1A3, CRISP3, THBS1, FMN1, and IL-10 were decreased. In conclusion, the gene expression profile of patients with ITP has established a foundation to study the gene mechanism of ITP progression.
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