Journal
RESULTS IN CHEMISTRY
Volume 3, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.rechem.2021.100175
Keywords
Knema furfuracea; Knemavane; Anti-inflammatory
Categories
Funding
- National Natural Science Foundation of China [31860097]
- Science and Technology Program of Yunnan Province [202101AT070134]
- Scientific Research Program of the Education Department of Yunnan Province [2014Z047]
- Key Laboratory of Higher Education in Yunnan [2016-5]
- Top Young Talent of Ten Thousand Talents Program of Yunnan Province
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Knema furfuracea is a tropical evergreen plant that belongs to the Myristicaceae family. Phytochemical investigation led to the isolation of 11 phenolic compounds, including a new flavonoid knemavane A. Compounds 1, 2, and 6 showed inhibitory activities against nitric oxide production in LPS-activated macrophages.
Knema furfuracea is a tropical evergreen plant, which belongs to Myristicaceae family. Phytochemical investigation on the twigs and leaves of K. furfuracea led to the isolation of 11 phenolic compounds, including a new flavonoid knemavane A (1). These compounds belong to flavonoids, lignans, and anarardic acids. Biological evaluation of the inhibitory activities of compounds 1-11 against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages showed that compounds 1 (IC50 = 13.79 mu M), 2 (IC50 = 9.28 mu M), and 6 (IC50 = 15.14 mu M) were active.
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