Journal
BIOMEDICAL JOURNAL
Volume 39, Issue 2, Pages 98-106Publisher
ELSEVIER
DOI: 10.1016/j.bj.2015.10.002
Keywords
Autophagy; Cancer; Mitochondria; Mitophagy; Oxidative stress; Reactive species
Funding
- UAB Brain Tumor SPORE Career Development Award
- University of Alabama at Birmingham Department of Cell, Developmental and Integrative Biology
- [CA1515122]
- [NIHR01-NS064090]
Ask authors/readers for more resources
Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species-induced damage to molecules and organelles. Redox regulation, metabolic plasticity, autophagy, and mitophagy play important and interactive roles in cancer hallmarks including sustained proliferation, activated invasion, and replicative immortality. However, the impact of these processes can differ depending on the signaling pathways altered in cancer, tumor type, tumor stage, and/or the differentiation state. Here, we highlight some of the representative studies on the impact of oxidative and nitrosative activities, mitochondrial bioenergetics, metabolism, and autophagy and mitophagy in the context of tumorigenesis. We discuss the implications of these processes for cellular activities in cancer for anti-cancer-based therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available