Social Functioning in Adults Born Very Preterm: Individual Participant Meta-analysis

CONTEXT: There is a lack of research on individual perceptions of social experiences and social relationships among very preterm (VP) adults compared with term-born peers. OBJECTIVE: To investigate self-perceived social functioning in adults born VP (<32 weeks' gestation) and/or with very low birth weight (VLBW) (<1500g) compared with term-born adults (>= 37 weeks' gestation) using an individual participant data (IPD) meta-analysis. DATA SOURCES: Two international consortia: Research on European Children and Adults born Preterm and Adults Born Preterm International Collaboration. STUDY SELECTION: Cohorts with outcomes assessed by using the Adult Self-Report Adaptive Functioning scales (friends, spouse/partner, family, job, and education) in both groups. DATA EXTRACTION: IPD from 5 eligible cohorts were collected. Raw-sumscores for each scale were standardized as z scores by using mean and SD of controls for each cohort. Pooled effect size was measured by difference (Delta) in means between groups. RESULTS: One-stage analyses (1285 participants) revealed significantly lower scores for relationships with friends in VP/VLBW adults compared with controls (Delta -0.37, 95% confidence interval [CI]: -0.61 to -0.13). Differences were similar after adjusting for sex, age, and socioeconomic status (Delta -0.39, 95% CI: -0.63 to -0.15) and after excluding participants with neurosensory impairment (Delta -0.34, 95% CI: -0.61 to -0.07). No significant differences were found in other domains. LIMITATIONS: Generalizability of research findings to VP survivors born in recent decades. CONCLUSIONS: VP/VLBW adults scored their relationship with friends lower but perceived their family and partner relationships, as well as work and educational experiences, as comparable to those of controls.

Automated summary

Very preterm/very low birth weight adults scored lower in relationships with friends compared to controls, but perceived their family and partner relationships, as well as work and educational experiences, as comparable. No significant differences were found in other domains.