Journal
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
Volume 64, Issue 4, Pages 171-177Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.retram.2016.09.003
Keywords
Hypertrophic scar; Chronic wound; Fibrosis; Mechanics
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [210820, 286920, 286720, 497202]
- Collaborative Health Research Programme (CIHR/NSERC) [1004005, 413783]
- Canada Foundation for Innovation and Ontario Research Fund (CFI/ORF) [26653]
Ask authors/readers for more resources
The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury. Too many myofibroblasts working for too long cause tissue contractures that ultimately obstruct organ function. Insufficient myofibroblast activation and activities, in turn, prevents normal wound healing. This short review puts a spotlight on the myofibroblast for those who seek therapeutic targets in the context of dysregulated tissue repair. Keep your myofibroblasts in balance is the message. (C) 2016 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available