Journal
IMMUNE NETWORK
Volume 16, Issue 6, Pages 330-336Publisher
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2016.16.6.330
Keywords
Regulatory T cell; Hepatitis B virus; Hepatitis C virus
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2014R1A1A3050293]
- National Research Foundation of Korea [2014R1A1A3050293] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4(+)CD25(+)Foxp3(+) Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.
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