Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 8, Issue 4, Pages 330-340Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v8.i4.330
Keywords
MicroRNA; Diagnosis; Prognosis; Colorectal cancer; Biomarkers
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Funding
- Municipal Natural Science Foundation of Beijing of China [5102039]
- National Natural Science Foundation of China [81101859, 81270379, 81070231]
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MicroRNAs (miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miRNAs in colorectal cancer (CRC) diagnosis. We also shed light on the important corresponding miRNA targets and on the major regulators of miRNAs. Furthermore, we discuss miRNA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miRNAs, the advantages of a therapeutic strategy based on the delivery of miRNA mimics are also mentioned. Together, miRNA seems to be an excellent tool for effectively monitoring and targeting CRC.
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