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Macrophages prevent hemorrhagic infarct transformation in murine stroke models
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Risk Assessment of Hemorrhagic Transformation of Acute Middle Cerebral Artery Stroke Using Multimodal CT
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Serum tight-junction proteins predict hemorrhagic transformation in ischemic stroke patients
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ANNALS OF NEUROLOGY (2011)
Neuroprotective effects of ultra-low-molecular-weight heparin in vitro and vivo models of ischemic injury
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HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator
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Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment
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Partial XBP1 Knockdown Does Not Affect Viability of Oligodendrocyte Precursor Cells Exposed to New Models of Hypoxia and Ischemia In Vitro
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Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice
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Central nervous system pericytes in health and disease
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17β-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia
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Measuring Permeability in Acute Ischemic Stroke
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HMGB1 and RAGE in Inflammation and Cancer
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Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia
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Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia
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Suppression of Hypoxia-Inducible Factor-1α and Its Downstream Genes Reduces Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Rat Model of Cerebral Ischemia
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Molecular mechanisms of microvascular failure in central nervous system injury-synergistic roles of NKCC1 and SUR1/TRPM4 A review
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Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia
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Lower coated-platelet levels are associated with early hemorrhagic transformation in patients with non-lacunar brain infarction
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The Science of Stroke: Mechanisms in Search of Treatments
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PROGRESS IN NEUROBIOLOGY (2010)
Plasma VAP-1/SSAO Activity Predicts Intracranial Hemorrhages and Adverse Neurological Outcome After Tissue Plasminogen Activator Treatment in Stroke
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High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia
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Predictors of Hemorrhage Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Role of Pial Collateral Formation
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CT Angiography Source Images Predict Final Infarct Extent in Patients with Basilar Artery Occlusion
V. Puetz et al.
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Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model
Masashi Maeda et al.
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Acute Hyperglycemia and Early Hemorrhagic Transformation in Ischemic Stroke
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Get With the Guidelines-Stroke Is Associated With Sustained Improvement in Care for Patients Hospitalized With Acute Stroke or Transient Ischemic Attack
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Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain
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Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
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A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke
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Ultrastructural and Temporal Changes of the Microvascular Basement Membrane and Astrocyte Interface Following Focal Cerebral Ischemia
Il Kwon et al.
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NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
Angela M. Brennan et al.
NATURE NEUROSCIENCE (2009)
Frequency and Determinants for Hemorrhagic Transformation of Cerebral Infarction
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VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
Azeb Tadesse Argaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Risk Assessment of Symptomatic Intracerebral Hemorrhage After Thrombolysis Using DWI-ASPECTS
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Minocycline and Tissue-Type Plasminogen Activator for Stroke Assessment of Interaction Potential
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Low Level of Low-Density Lipoprotein Cholesterol Increases Hemorrhagic Transformation in Large Artery Atherothrombosis but Not in Cardioembolism
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Dynamic Perfusion CT Assessment of the Blood-Brain Barrier Permeability: First Pass versus Delayed Acquisition
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PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
Marlene T. Mathews et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel
Jae-Yong Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome
Vanja Basic Kes et al.
CLINICAL BIOCHEMISTRY (2008)
Role of inflammatory markers in brain ischemia
Manuel Rodriguez-Yanez et al.
CURRENT OPINION IN NEUROLOGY (2008)
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice
Marianne Haddad et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
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INTERNATIONAL JOURNAL OF STROKE (2008)
A Risk Score to Predict Intracranial Hemorrhage After Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke
Brett Cucchiara et al.
Journal of Stroke & Cerebrovascular Diseases (2008)
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Enming J. Su et al.
NATURE MEDICINE (2008)
The HAT Score A simple grading scale for predicting hemorrhage after thrombolysis
M. Lou et al.
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Reperfusion-Associated Hemorrhagic Transformation in SHR Rats Evidence of Symptomatic Parenchymal Hematoma
Erica C. Henning et al.
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Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke
Yoshihiro Murata et al.
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Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial
Mei Yong et al.
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Minocycline treatment in acute stroke - An open-label, evaluator-blinded study
Y. Lampl et al.
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STROKE (2007)
Neuronal chemokines: Versatile messengers in central nervous system cell interaction
A. H. de Haas et al.
MOLECULAR NEUROBIOLOGY (2007)
Tumor necrosis factor-α is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits
Paul A. Lapchak
BRAIN RESEARCH (2007)
Endothelial sulfonylurea receptor 1-regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury
J. Marc Simard et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Microplasmin and tissue plasminogen activator: Comparison of therapeutic effects in rat stroke model at multiparametric MR imaging
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RADIOLOGY (2007)
Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke -: A multicenter confirmatory study
Mar Castellanos et al.
STROKE (2007)
FK-506 extended the therapeutic time window for thrombolysis without increasing the risk of hemorrhagic transformation in an embolic rat stroke model
Seiji Okubo et al.
BRAIN RESEARCH (2007)
Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit
Rohini Polavarapu et al.
BLOOD (2007)
The impact of recanalization on ischemic stroke outcome - A meta-analysis
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Two tales:: Hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia -: MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hours
Goetz Thomalla et al.
STROKE (2007)
Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke
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Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury
Robert M. Weston et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke
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Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC
Karni S. Moshal et al.
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Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
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NATURE MEDICINE (2006)
Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats
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Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
Jun Yin et al.
JOURNAL OF PINEAL RESEARCH (2006)
Role of fibrinogen levels and factor XIII V34L polymorphism in thrombolytic therapy in stroke patients
Rocio Gonzalez-Conejero et al.
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Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study
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BMJ-BRITISH MEDICAL JOURNAL (2006)
Selective MCA occlusion: A precise embolic stroke model
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JOURNAL OF NEUROSCIENCE METHODS (2006)
Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury
Oliver B. Dimitrijevic et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)
Role of matrix metalloproteinases in delayed cortical responses after stroke
BQ Zhao et al.
NATURE MEDICINE (2006)
Pretreatment hemostatic markers of symptomatic intracerebral hemorrhage in patients treated with tissue plasminogen activator
D Cocho et al.
STROKE (2006)
Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice
TY Chen et al.
JOURNAL OF PINEAL RESEARCH (2006)
1,026 experimental treatments in acute stroke
VE O'Collins et al.
ANNALS OF NEUROLOGY (2006)
Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke
P Trouillas et al.
STROKE (2006)
Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
JM Gidday et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats
T Abumiya et al.
BRAIN RESEARCH (2005)
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4
B Nilius et al.
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Complexity of Astrocyte-Motor Neuron Interactions in Amyotrophic Lateral Sclerosis
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Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
DM Kuhn et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Admission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activator
M Ribo et al.
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Mouse model of microembolic stroke and reperfusion
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Targets for vascular protection after acute ischemic stroke
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STROKE (2004)
Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage
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Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model
L Zhang et al.
STROKE (2004)
Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke
M Castellanos et al.
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HIf1 and oxygen sensing in the brain
FR Sharp et al.
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Microsphere-induced embolic stroke: An MRI study
O Mayzel-Oreg et al.
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GSK3 inhibitors: Development and therapeutic potential
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NATURE REVIEWS DRUG DISCOVERY (2004)
Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke model
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NEUROLOGICAL RESEARCH (2003)
Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke
M Castellanos et al.
STROKE (2003)
The nonpeptide glycoprotein Ilb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke
PA Lapchak et al.
STROKE (2002)
Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke
DC Morris et al.
STROKE (2001)
Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice -: Role of hemodynamic alterations
E Kilic et al.
STROKE (2001)
Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats
Y Matsuo et al.
STROKE (2001)
Early diagnosis of hemorrhagic transformation: Diffusion/perfusion-weighted MRI versus CT scan
N Nighoghossian et al.
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The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
O Nicole et al.
NATURE MEDICINE (2001)
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
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Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
GL Semenza
JOURNAL OF CLINICAL INVESTIGATION (2000)