Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 3, Issue 4, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofw175
Keywords
adenosine analog; antiviral; mouse model; Zika virus
Categories
Funding
- State Key Laboratory of Pathogen and Biosecurity [SKLPBS1601]
- Guangzhou Science and Technology Program for Public Wellbeing [2014Y2-00185, 2014Y2-00550]
- National Natural Science Foundation (NSFC) of China [31470265]
- NSFC of China [81522025, 81661130162]
- Academy of Medical Sciences, UK
- NIH [AI087856]
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The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
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