Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 4, Issue 1, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofw261
Keywords
CARD9; central nervous system mycosis; chronic lymphoid malignancies; cryptococcosis; ibrutinib
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Funding
- National Institute of Allergy and Infectious Diseases [5T32AI100851-03]
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We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.
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