Journal
ADVANCES IN TRADITIONAL MEDICINE
Volume 22, Issue 1, Pages 141-154Publisher
SPRINGER
DOI: 10.1007/s13596-020-00528-5
Keywords
Achyranthes aspera L.; Antidepressant; Anxiolytic; Thrombolytic; In silico
Categories
Ask authors/readers for more resources
This research investigates the pharmacological properties of the methanol extract of Achyranthes aspera L., showing its potential as an antidepressant, anxiolytic, and thrombolytic. In silico studies demonstrate promising binding affinity of the extract to various proteins. Overall, the study highlights the medicinal potential of A. aspera.
Achyranthes aspera L. (Prickly Chaff flower) is an imperative Asian herb that has been known for numerous healing powers. The aim of this research is to investigate the pharmacological i.e., antidepressant and anxiolytic properties of the methanol extract of aerial part of A. aspera (MEAA) by in vivo and in silico approaches. Additionally, thrombolytic potential of the crude extract has also been explored. The antidepressant and anxiolytic investigations were performed by force swimming test (FST), tail suspension test (TST), and hole board test (HBT) in mice, whereas clot lysis activity test was conducted using thrombolytic experimental method. Furthermore, in silico studies were appraised with Discovery studio, PyRx, UCSF Chimera whereas, PASS prediction, and ADME/T was implemented using online tools. Treatment with MEAA revealed significant (p < 0.05) reduction of immobility time in FST and TST, increased head dipping and decreased the latency of time in HBT. Besides, MEAA produced significant (p < 0.001) clot lysis activity at a minimum dose. In the computer-aided approach, among all the proteins, the docking score has been revealed ranging from - 2.31 kcal/mol to - 7.4 kcal/mol. Spathulenol, diazepam and hydroquinone showed the best binding affinity and all compounds were found safe in ADME/T study. The outcomes of this research demonstrate that MEAA may provide potential for mitigating depression, anxiety, and coagulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available