Journal
JOURNAL OF MENTAL HEALTH
Volume 31, Issue 4, Pages 506-516Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/09638237.2021.1875422
Keywords
EQ-5D-5L; depression; utility index; psychometric properties; item response theory; economic evaluation
Categories
Funding
- Instituto de Salud Carlos III [PI13/00560, PI13/00518, PI13/00648]
- European Regional Development Fund
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The study on 433 patients with major depression demonstrated that the EQ-5D-5L questionnaire has good psychometric properties and can be used as a tool for outcome assessment and economic evaluation. There may be some item functional differences in different age groups.
Background The EQ-5D is one of the most recommended questionnaires for cost-effectiveness studies. Aims To study the psychometric properties of the EQ-5D-5L in patients with major depression. Methods This prospective observational study included 433 patients with major depression who completed the EQ-5D-5L and Patient Health Questionnaire-9 (PHQ-9) questionnaires at baseline, of whom 310 also did six months later. The structural validity was assessed by confirmatory factor analysis, the item functioning by item response analysis, and reliability by Cronbach's alpha. Convergent validity and known-groups validity was studied using the PHQ-9 and a general health question. To assess responsiveness effect sizes were calculated. Results The results supported the unidimensionality and showed adequate item functioning, with somewhat age-related item differential functioning for the mobility dimension. Cronbach's alpha was 0.77. The EQ-5D-5L showed a high correlation with the PHQ-9 and general health. The more severe the depression level and the poorer the general health, the lower the EQ-5D-5L scores (p < 0.001). Responsiveness parameters showed moderate changes among improved patients. Conclusions These findings support the adequate psychometric properties of the EQ-5D-5L in patients with major depression. It could be very useful for clinicians and researchers as an outcome measure and for use in economic evaluation.
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