4.5 Article

Perinatal Factors in Newborn Are Insidious Risk Factors for Childhood Autism Spectrum Disorders: A Population-based Study

Journal

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 52, Issue 1, Pages 52-60

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-021-04921-0

Keywords

Autism; Craniofacial anomalies; Neonatal jaundice; Hypoglycemia; Intrauterine growth retardation

Funding

  1. Chung Shan Medical University Hospital [CSH-2021-C-012, CSH-2015-A-009]

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This research analyzed the prevalence of autism spectrum disorders in Taiwanese children and its association with perinatal risk factors. The study found significant associations between neonatal jaundice, hypoglycemia, intrauterine growth retardation, craniofacial anomalies, and autism spectrum disorders.
We analyzed claims data from the Taiwan National Health Insurance database, which contains data of 23.5 million Taiwan residents. We included children born after January 1, 2000 who had received a diagnosis of autism spectrum disorders (ASD). Patients who were not diagnosed with ASD were included in the control group. The ASD prevalence was 517 in 62,051 (0.83%) children. Neonatal jaundice, hypoglycemia, intrauterine growth retardation (IUGR), and craniofacial anomalies (CFA) differed significantly between the ASD and control groups. After logistic regressive analysis, the adjusted odds ratios of IUGR, CFA, neonatal hypoglycemia, and neonatal jaundice were 8.58, 7.37, 3.83, and 1.32, respectively. Those insidiously perinatal risk factors, namely CFA, IUGR, neonatal hypoglycemia, and neonatal jaundice, could increase the risk of ASD.

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