Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 52, Issue 3, Pages 1374-1387Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-021-05002-y
Keywords
Autism spectrum disorders (ASD); Gut microbiota; Microbiota-gut-brain axis; Systematic review; Meta-analysis
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This study found lower relative abundance of Streptococcus and Bifidobacterium genera in the gut microbiota of children with ASD. The Bifidobacterium genera play a significant role in ASD, but differences between studies are attributed to factors such as reporting bias.
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD+ = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
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