Journal
HEAD & NECK PATHOLOGY
Volume 16, Issue 1, Pages 314-321Publisher
SPRINGER
DOI: 10.1007/s12105-021-01344-2
Keywords
Lobular carcinoma; Breast; Cadherins; Salivary glands; CTNNA1; Salivary duct carcinoma
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This case report describes a 62-year-old male patient with a salivary gland tumor that exhibited complex pathological features. The treatment included surgical resection, immunotherapy, and chemotherapy, and the patient is currently alive.
Salivary and mammary glands are both exocrine organs sharing multiple tumorigenic processes. To the best of our knowledge, salivary gland tumors mimicking invasive lobular carcinoma of the breast have not yet been described. Herein, we report a case of a 62-year-old male who presented with progressive facial paralysis. Pathologic examination revealed an ill-defined epithelial neoplasm exhibiting discohesive growth set within an extensively fibrotic stroma. Both perineural and intraneural invasion were present. E-cadherin and p120 immunostaining showed aberrant cytoplasmic expression. Targeted next-generation sequencing detected a frameshift mutation of the CTNNA1 gene as the only known pathogenic variant. The patient was treated with surgical resection, immunotherapy, and chemotherapy. Currently, he is alive with disease twenty months after disease onset.
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