Journal
STEM CELL REVIEWS AND REPORTS
Volume 18, Issue 1, Pages 198-213Publisher
SPRINGER
DOI: 10.1007/s12015-021-10216-9
Keywords
Cancer Stem Cell; Metaboloepigenetics; Metabostemness; Mitophagy; Oncometabolism
Funding
- Department of Biotechnology [BT/PR23304/MED/30/1823/2017]
- Ministry of Science and Technology, Government of India
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Cancer stem cells (CSCs) are a rare subset of malignant cells with stem cell-like features that acquire stemness through metabolic rewiring and epigenetic reprogramming, influencing tumor progression. Specific drugs targeting the metaboloepigenetic circuitry of CSCs may serve as potential cancer therapeutics.
Cancer stem cells (CSCs) are rare populations of malignant cells with stem cell-like features of self-renewal, uninterrupted differentiation, tumorigenicity, and resistance to conventional therapeutic agents, and these cells have a decisive role in treatment failure and tumor relapse. The self-renewal potential of CSCs with atypical activation of developmental signaling pathways involves the maintenance of stemness to support cancer progression. The acquisition of stemness in CSCs has been accomplished through genetic and epigenetic rewiring following the metabolic switch. In this context, metabostemness denotes the metabolic parameters that essentially govern the epitranscriptional gene reprogramming mechanism to dedifferentiate tumor cells into CSCs. Several metabolites often referred to as oncometabolites can directly remodel chromatin structure and thereby influence the operation of epitranscriptional circuits. This integrated metaboloepigenetic dimension of CSCs favors the differentiated cells to move in dedifferentiated macrostates. Some metabolic events might perform as early drivers of epitranscriptional reprogramming; however, subsequent metabolic hits may govern the retention of stemness properties in the tumor mass. Interestingly, selective removal of mitochondria through autophagy can promote metabolic plasticity and alter metabolic states during differentiation and dedifferentiation. In this connection, novel metabostemness-specific drugs can be generated as potential cancer therapeutics to target the metaboloepigenetic circuitry to eliminate CSCs.
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