Journal
MARINE LIFE SCIENCE & TECHNOLOGY
Volume 4, Issue 1, Pages 74-87Publisher
SPRINGERNATURE
DOI: 10.1007/s42995-021-00116-9
Keywords
Chitosan; L-Lysine; L-Glutamic acid; alpha beta-Glycerophosphate; Thermosensitive hydrogel; In vitro release
Categories
Funding
- Natural Science Foundation of Henan Province [182300410213]
- National Natural Science Foundation of China [51103035]
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Chitosan-amino acid thermosensitive hydrogels demonstrate good thermosensitivity and a three-dimensional network structure, with sustained release effects even after the addition of model drugs.
Chitosan/glycerophosphate thermosensitive hydrogel crosslinked physically was a potential drug delivery carrier; however, long gelation time limits its application. Here, chitosan-amino acid (AA) thermosensitive hydrogels were prepared from chitosan (CS), alpha beta-glycerophosphate (GP), and L-lysine (Lys) or L-glutamic acid (Glu). The prepared CS-Lys/GP and CS-Glu/GP hydrogel showed good thermosensitivity and could form gels in a short time. The optimal parameters of CS-Lys/GP hydrogel were that the concentration of CS-Lys was 2.5%, the ratio of CS/Lys was 3.5/1.0, the ratio of CS-Lys/GP was 4.5/1.0. The optimal parameters of CS-Glu/GP hydrogel were that the concentration of CS-Glu was 3.0%, the ratio of CS/Glu was 2.0/1.0, and the ratio of CS-Glu/GP was 4.0/1.5. Chitosan-amino acid (CS-AA) thermosensitive hydrogel had a three-dimensional network structure. The addition of model drug tinidazole (TNZ) had no obvious effect on the structure of hydrogel. The results of infrared spectroscopy showed that there were hydrogen bonds between amino acids and chitosan. In vitro release results showed that CS-Lys/GP and CS-Glu/GP thermosensitive hydrogels had sustained release effects. Thus, the chitosan-amino acid thermosensitive hydrogels hold great potential as a sustained release drug delivery system.
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