4.3 Article

Irisin alleviates FFA induced β-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Inceptor counteracts insulin signalling in β-cells to control glycaemia

Ansarullah et al.

Summary: The discovery of inceptor, an inhibitor of insulin receptor (INSR) and IGF1 receptor (IGF1R) signalling in mouse beta-cells, sheds light on a potential molecular target for INSR-IGF1R sensitization and diabetes therapy. The study shows that inceptor plays a role in shielding insulin-producing beta-cells from constitutive pathway activation, which could have implications for improving glucose tolerance in vivo.

NATURE (2021)

Article Food Science & Technology

Vitamin D Deficiency Induces Insulin Resistance and Re-Supplementation Attenuates Hepatic Glucose Output via the PI3K-AKT-FOXO1 Mediated Pathway

Shivaprakash Jagalur Mutt et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

Review Rehabilitation

Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis

A. Sampath Kumar et al.

ANNALS OF PHYSICAL AND REHABILITATION MEDICINE (2019)

Article Biochemistry & Molecular Biology

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway

Liang Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Article Physiology

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

Brianne L. Guilford et al.

PHYSIOLOGICAL REPORTS (2017)

Article Endocrinology & Metabolism

Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis

Chun Zhang et al.

JOURNAL OF DIABETES (2016)

Article Biochemistry & Molecular Biology

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

Xiao-Qing Xiong et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Cell Biology

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

Mark P. Jedrychowski et al.

CELL METABOLISM (2015)

Article Cell Biology

New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro

Min-Jung Park et al.

CELLULAR SIGNALLING (2015)

Article Cardiac & Cardiovascular Systems

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses

Di Zhu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Endocrinology & Metabolism

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

J. Y. Huh et al.

INTERNATIONAL JOURNAL OF OBESITY (2014)

Review Endocrinology & Metabolism

β-Cell inflammation in human type 2 diabetes and the role of autophagy

L. Marselli et al.

DIABETES OBESITY & METABOLISM (2013)

Article Endocrinology & Metabolism

Lower circulating irisin is associated with type 2 diabetes mellitus

Jian-Jun Liu et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2013)

Editorial Material Biochemistry & Molecular Biology

Nuclear FoxO1 inflames insulin resistance

John E. Dominy et al.

EMBO JOURNAL (2010)

Review Medicine, General & Internal

GENOMIC MEDICINE Genomics, Type 2 Diabetes, and Obesity

Mark I. McCarthy

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Gastroenterology & Hepatology

TLR4 and Insulin Resistance

Jane J. Kim et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2010)

Article Endocrinology & Metabolism

Increased number of islet-associated macrophages in type 2 diabetes

Jan A. Ehses et al.

DIABETES (2007)

Article Medicine, Research & Experimental

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

T Kitamura et al.

JOURNAL OF CLINICAL INVESTIGATION (2002)