Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 605, Issue -, Pages 500-512Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.07.116
Keywords
Perovskite quantum dots; (NH4)(x)Cs1-xPbBr3; Optical imaging; Photothermal therapy; Caveolin-mediated endocytosis
Categories
Funding
- Ministry of Science and Technology of the Republic of China [MOST 108-2218-E-011-017-MY3, 110-2113-M-011003]
- NTUST [NPUST-NYUST-NTUST-109-06]
- Taiwan Building Technology Center from The Featured Areas Research Center Program
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A facile strategy for highly efficient (NH4)(x)Cs1-xPbBr3 quantum dots synthesis has been reported for the first time, showing enhanced photoluminescence quantum yield, photostability, and long-term storage stability. Conjugation with a photothermal dye demonstrated good water dispersibility and high photothermal conversion efficiency.
Herein, we report for the first time a facile strategy for the highly efficient (NH4)(x)Cs1-xPbBr3 quantum dots (QDs). By modulating the amount of ammonium, (NH4)(x)Cs1-xPbBr3 QDs with different photoluminescence (PL) quantum yields (QY) were synthesized. The results of X-ray diffraction and X-ray photoelectron spectroscopy showed that the crystal structure of (NH4)(x)Cs1-xPbBr3 was altered by incorporation of NH4+ cations into the CsPbBr3Y lattice. The (NH4)(x)Cs1-xPbBr3 QDs showed enhanced PL QY, higher photostability, and long-term storage stability compared to CsPbBr3 QDs. Furthermore, (NH4)(x)Cs1-xPbBr3 QDs could be conjugated with a photothermal dye (IR780) via a one-pot reaction using poly(styrene-co-maleic anhydride) and IR780-MPTS. To the best of our knowledge, the present work is the first attempt integrating perovskite QDs and phototherapeutic molecules into one system (abbreviated as PQD-IR780), demonstrating good water dispersibility and high photothermal conversion efficiency of 57.85%. In vitro experiments performed to examine subcellular uptake showed high fluorescence brightness was observed in HeLa, B16F1, and HepG2 cancer cells cultured with PQD-IR780. The results indicate that the internalization mechanism for uptaking of PQD-IR780 inside HeLa cells is energy-dependent and caveolin-mediated endocytosis. The in vitro cell viability assays and photothermal therapy revealed that PQD-IR780 showed good biocompatibility and can induce hyperthermia upon laser irradiation. (C) 2021 Elsevier Inc. All rights reserved.
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