Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology

Automated summary

Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections, but the emergence of mobile Tet(X) enzymes poses a challenge to antibacterial therapy and food/environmental security. This review presents various Tet(X) variants, discussing their structure, action, evolutional origin, and potential inhibitors to improve understanding of Tet(X)-mediated tigecycline resistance.