Journal
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
Volume 12, Issue 4, Pages 5610-5624Publisher
BIOINTERFACE RESEARCH APPLIED CHEMISTRY
DOI: 10.33263/BRIAC124.56105624
Keywords
polymer composites; polylactic acid; tricalcium phosphate; bioactivity assessment; tissue engineering
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Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina)
- Fondo para la Investigacion Cientifica y Tecnologica (FONCyT, Argentina)
- Universidad Nacional de Cuyo (UNCuyo, Argentina)
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The development of bioactive and composite materials for tissue engineering applications is a topic of global research. In this study, PLA/TCP composite materials were fabricated and their bioactive response and mechanical properties were evaluated in simulated body fluid. The results suggest that these composites have potential applications in bone tissue engineering.
The development of bioactive and composite materials for tissue engineering applications is being investigated worldwide. Many approaches have been published by including combinations of resorbable polymers with hydroxyapatite (HA), tricalcium phosphate (TCP), bioactive glasses and glass-ceramics in different scaffolds architectures. Taking into account these antecedents, porous polylactic acid (PLA)/TCP composites were fabricated by employing dissolution-leaching technic from PLA/chloroform solution (10, 15, and 20 wt % of TCP). Composite scaffolds exhibited porosity values similar to 1.3 times higher when compared to PLA foams. Their bioactive response of the composite foams after immersion in a simulated body fluid (SBF) was studied by X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR-ATR). By XRD analysis, diffraction peaks attributed to hydroxyapatite deposition were observed; and by FTIR-ATR, new absorption bands corresponding to HA were detected. Regarding mechanical properties, an increasing tendency on elastic Young's modulus values was observed at higher TCP concentrations. These results envision the feasibility of using these composites as precursors for bone tissue materials engineering.
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