Study and Optimization of the Synthesis of Apatitic Nanoparticles by the Dissolution/Precipitation Method

In this work, we have studied and optimized the technique of the synthesis of hydroxyapatite by a new method called dissolution/reprecipitation, with the aim of finding the appropriate operating conditions for the synthesis of apatitic nanoparticles. The optimum value of the size of the apatitic nanoparticles being 65 nm. The theoretical results presented by this experimental design have been verified: the experimental results are similar to the results estimated by this model. Scanning electron microscopy images confirm the morphology of apatitic nanoparticles and verify the validity of our mathematical modeling. Analysis by infrared spectroscopy and X-ray diffraction of the products obtained by the method shows that the final phases are pure and stoichiometric. The method of dissolving-reprecipitating apatitic nanoparticles has several advantages over other methods, such as purity and nanoscale sizes of the final phase. The new dissolution / reprecipitation method is a synthesis technique which makes it possible to prepare very pure hydroxyapatite nanoparticles without the intervention of precursors (salts) which generally generate impurities in the final product. The new method can then be used in the synthesis of apatitic biocomposites using biopolymers.

Automated summary

In this study, a new dissolution/reprecipitation method was used to synthesize hydroxyapatite, resulting in nanoparticles with optimal size and purity. The experimental results are consistent with the theoretical model, confirming the validity of the mathematical modeling.