Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 1, Pages 5-10Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.1c00617
Keywords
flavivirus; virus-targeting; host-targeting; emerging virus
Categories
Funding
- Ministerio de Ciencia e Innovacion, Agencia Estatal de Investigacion [PID2019-105117RR-C22, PID2019-105117RR-C21, MCIN/AEI/10.13039/501100011033]
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This viewpoint discusses the advantages and disadvantages of virus-targeting antivirals and host-targeting drugs as potential therapies for Flavivirus infections. These two approaches may be complementary, each with its own strengths and weaknesses.
The COVID pandemic has evidenced how vulnerable we are to emerging infectious diseases and how short our current armamentarium is. Flavivirus, single stranded RNA viruses transmitted by arthropods, are considered a global health challenge. No drugs to treat these infections have been approved. In this Viewpoint, we analyze the advantages and disadvantages of two different, but probably also complementary, therapeutic approaches: virus-targeting antivirals and host-targeting drugs.
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