Related references
Note: Only part of the references are listed.Ubiquitin-specific protease 28 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity by regulating MYC expression
Zengwu Wang et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2016)
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer
Rania Abdelmaksoud-Dammak et al.
TUMOR BIOLOGY (2016)
DUBs, the regulation of cell identity and disease (vol 465, pg 1, 2014)
J. Heideker et al.
BIOCHEMICAL JOURNAL (2015)
Cezanne regulates E2F1-dependent HIF2α expressiond
Sonia Moniz et al.
JOURNAL OF CELL SCIENCE (2015)
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma
Jia-hong Wang et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
Deubiquitinase inhibition as a cancer therapeutic strategy
Padraig D'Arcy et al.
PHARMACOLOGY & THERAPEUTICS (2015)
The demographics of the ubiquitin system
Michael J. Clague et al.
TRENDS IN CELL BIOLOGY (2015)
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways
Yu-yu Gu et al.
TUMOR BIOLOGY (2015)
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
Yoko Goto et al.
NATURE COMMUNICATIONS (2015)
Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3γ
Jin-Ock Kim et al.
ONCOTARGET (2015)
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression
Sajjad Hussain et al.
ONCOTARGET (2015)
Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma
Mei Yee Koh et al.
CANCER RESEARCH (2015)
Mutations in the deubiquitinase gene USP8 cause Cushing's disease
Martin Reincke et al.
NATURE GENETICS (2015)
TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation
Ivano Amelio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets
Padraig D'Arcy et al.
CLINICAL CANCER RESEARCH (2014)
HIF1 alpha deubiquitination by USP8 is essential for ciliogenesis in normoxia
Albino Troilo et al.
EMBO REPORTS (2014)
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
Anja Bremm et al.
EMBO REPORTS (2014)
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
Xingnan Zheng et al.
GENES & DEVELOPMENT (2014)
MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner
Shweta Joshi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
USP28 is a potential prognostic marker for bladder cancer
Guiying Guo et al.
TUMOR BIOLOGY (2014)
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy
Jianying Guo et al.
ONCOTARGET (2014)
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis
Arpita Roy et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
Joao Vasco Ferreira et al.
AUTOPHAGY (2013)
An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
Kelly Velasco et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability
John S. Bett et al.
BIOCHEMICAL JOURNAL (2013)
TRAF6 Upregulates Expression of HIF-1α and Promotes Tumor Angiogenesis
Heng Sun et al.
CANCER RESEARCH (2013)
Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination
Le A. Luong et al.
CIRCULATION RESEARCH (2013)
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
Maimon E. Hubbi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Downregulation of PHLPP Expression Contributes to Hypoxia-Induced Resistance to Chemotherapy in Colon Cancer Cells
Yang-An Wen et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
Shireen A. Sarraf et al.
NATURE (2013)
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer
X. Li et al.
ONCOGENE (2013)
Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells
Jin-Gu Lee et al.
NATURE COMMUNICATIONS (2013)
The Ubiquitin Code
David Komander et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
Daniela Flugel et al.
BLOOD (2012)
Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia
Mikael Altun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling
Ilkka Paatero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Deubiquitinases in cancer: new functions and therapeutic options
J. M. Fraile et al.
ONCOGENE (2012)
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Gregg L. Semenza
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
HIF1 alpha and HIF2 alpha: sibling rivalry in hypoxic tumour growth and progression
Brian Keith et al.
NATURE REVIEWS CANCER (2012)
CYLD: a deubiquitination enzyme with multiple roles in cancer
Ramin Massoumi
FUTURE ONCOLOGY (2011)
USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains
Marzia Scortegagna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Negative Regulation of HIF-1α by an FBW7-Mediated Degradation Pathway During Hypoxia
Jessica M. Cassavaugh et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes
Matteo Colombo et al.
CHEMMEDCHEM (2010)
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
Weibo Luo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
Anja Bremm et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2 alpha
Martijn van Hagen et al.
NUCLEIC ACIDS RESEARCH (2010)
The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal
Carla Figueira Bento et al.
PLOS ONE (2010)
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
Elana S. Ehrlich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inactivation of the CYLD Deubiquitinase by HPV E6 Mediates Hypoxia-Induced NF-κB Activation
Jiabin An et al.
CANCER CELL (2008)
Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation
Mei Yee Koh et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
PHDs overactivation during chronic hypoxia desensitizes HIFα and protects cells from necrosis
Amandine Ginouves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1α
Jin Hyen Baek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The ubiquitin-specific protease USP28 is required for MYC stability
Nikita Popov et al.
NATURE CELL BIOLOGY (2007)
HIF-1α and CA IX staining in invasive breast carcinomas:: Prognosis and treatment outcome
Cynthia Trastour et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
被撤回的出版物: Siah-1 facilitates lubiquitination and degradation of factor inhibiting HIF-1α (FIH) (Retracted article. See vol. 388, pg. 618, 2009)
Hiromasa Fukuba et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
RACK1 competes with HSP90 for binding to HIF-1α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1α
Ye V. Liu et al.
MOLECULAR CELL (2007)
Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1α
J Zhou et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
N Pescador et al.
BIOCHEMICAL JOURNAL (2005)
VHLprotein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α
ZB Li et al.
EMBO REPORTS (2005)
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
V Quesada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1α abundance, and modulates physiological responses to hypoxia
K Nakayama et al.
CELL (2004)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1α by a von Hippel-Lindau protein-independent mechanism
TTL Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
JS Isaacs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor
ZB Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
D Lando et al.
SCIENCE (2002)
A conserved family of prolyl-4-hydroxylases that modify HIF
RK Bruick et al.
SCIENCE (2001)
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein et al.
CELL (2001)
Hypoxia-inducible factor-1α (HIF-1α) escapes O2-driven proteasomal degradation irrespective of its subcellular localization:: nucleus or cytoplasm
E Berra et al.
EMBO REPORTS (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
Identification of the familial cylindromatosis tumour-suppressor gene
GR Bignell et al.
NATURE GENETICS (2000)
Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13
M Takahashi et al.
HUMAN GENETICS (2000)