Journal
AGING AND DISEASE
Volume 13, Issue 4, Pages 1252-1266Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2021.1215
Keywords
Alzheimer's disease; gut microbiota; short-chain fatty acids
Categories
Funding
- National Natural Science Foundation of China [81971014]
- Shanghai Municipal Commission of Health and Family Planning [20184Y0056]
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Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.
Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. SCFAs participate a number of physiological and pathological processes in the human body, such as host metabolism, immune regulation, appetite regulation. Recent studies on gut-brain interaction have shown that SCFAs are important mediators of gut-brain interactions and are involved in the occurrence and development of many neurodegenerative diseases, including Alzheimer's disease. This review summarizes the current research on the potential roles and mechanisms of SCFAs in AD. First, we introduce the metabolic distribution, specific receptors and signaling pathways of SCFAs in human body. The concentration levels of SCFAs in AD patient/animal models are then summarized. In addition, we illustrate the effects and mechanisms of SCFAs on the cognitive level, pathological features (A ss and tau) and neuroinflammation in AD. Finally, we analyze the translational value of SCFAs as potential therapeutic targets for the treatment of AD.
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