Journal
KOREAN JOURNAL OF PAIN
Volume 35, Issue 1, Pages 43-58Publisher
KOREAN PAIN SOC
DOI: 10.3344/kjp.2022.35.1.43
Keywords
Bibliometrics; Cell Engineering; Chronic Pain; GABAergic Neurons; Gam-ma-Aminobutyric Acid; Hyperalgesia; Neural Stem Cells; Neuralgia; Pain Manage-ment; Spinal Cord Injuries
Categories
Funding
- Iran University of Medical Sciences
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The efficacy of GABAergic neural precursor cells in managing neuropathic pain was determined through a systematic review and meta-analysis. The results showed that these cells have a moderate level of effectiveness in improving symptoms of allodynia and hyperalgesia, especially in rats. Genetically modified cells were found to be more effective in improving pain symptoms.
Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.
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