PEDOT:PSS/PVA-Nanofibers-Decorated Conducting Paper for Cancer Diagnostics

The development of a flexible, label free, low-cost, and environment friendly biosensor platform is reported for sensitive and rapid detection of cancer biomarker based on poly(3,4-ethylenedioxythiophene): poly(4-styrenesulfonate)/polyvinyl alcohol nanofiber decorated conducting paper. This conducting paper based biosensor demonstrates improved sensing performance with linear detection range of 0.2-25 ng mL(-1), high sensitivity of 14.2 mu A ng(-1) mL cm(-2), and shelf life of 22 days for a carcinoembryonic antigen (cancer biomarker) detection. This modified conducting paper electrode is a promising alternative over expensive conventional electrodes (indium tin oxide, gold, and glassy carbon) for fabrication of smart point of care devices.