Journal
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
Volume 60, Issue 1, Pages 27-33Publisher
NATL INST SCIENCE COMMUNICATION-NISCAIR
Keywords
Molecular docking; Neurodegenerative disorder; alpha-Synuclein
Categories
Funding
- University Grants Commission (UGC), New Delhi as UGC Women Post-Doctoral Fellowship [F.151/2014-15/PDFWM-2014-15-GE-UTT-22847 (SA-II)]
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Parkinson's Disease (PD) is a progressive neurodegenerative disorder that currently has no permanent cure. Myricetin, a common plant derived flavonoid, has been shown to delay cognitive impairments in transgenic Drosophila expressing human alpha-synuclein, possibly through a positive interaction with the protein.
Parkinson's Disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons. Despite the availability of many drugs to ease the life of PD patients, there is no permanent cure until now. Now-a-days, there has been a considerable attention towards the use of herbal products to treat PD patients worldwide due to less side effects. In this context, here we investigated myricetin, a common plant derived flavonoid, on the cognitive impairments exhibited by the transgenic Drosophila expressing human alpha-synuclein in the neurons. The PD flies were allowed to feed on the diet having 10, 20 and 40 mu M of myricetin for 24 days and then assayed for cognitive impairments. The exposure of myricetin showed a dose dependent significant delay in the cognitive impairments. Molecular docking studies showed the positive interaction between myricetin and alpha-synuclein. The results suggest a protective effect of myricetin against the cognitive impairments.
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