The effect of different solvent systems on physical properties of electrospun poly(glycerol sebacate)/poly(e-caprolactone) blend

Solvent type and solution viscosity are of great importance in affecting different traits of the electrospun scaffolds. This study aims to highlight the effect of different solvents on physicomechanical properties of PGS/PCL blend electrospun scaffolds. The PGS:PCL (2:1) blends were dissolved in five different solvent systems including DMF, DCM, DMSO, CF-AC, and CF-EtOH, with the final concentration of 18% w/v. Analyzing morphology indicated a more uniform fiber diameter and smaller pore size in PGS/PCL//CF-AC scaffolds. Also, the mechanical parameters were improved by the solvent upon using CF-AC more than DMF, correlated to better solution viscosity, spinnability and uniform fiber distribution.

Automated summary

Solvent type and solution viscosity have significant effects on the characteristics of electrospun scaffolds. This study investigates the impact of different solvents on the physicomechanical properties of PGS/PCL blend electrospun scaffolds. The results show that PGS/PCL/CF-AC scaffolds have more uniform fiber diameter and smaller pore size. Moreover, CF-AC solvent has a greater influence on the mechanical parameters compared to DMF, due to better solution viscosity, spinnability, and fiber distribution uniformity.