Journal
CANCERS
Volume 8, Issue 6, Pages -Publisher
MDPI AG
DOI: 10.3390/cancers8060056
Keywords
triple negative breast cancer; immunoprevention; immunotherapy; cancer vaccine; alpha-lactalbumin
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Funding
- Shield Biotech, Inc.
- Cleveland, OH, USA
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We have proposed that safe and effective protection against the development of adult onset cancers may be achieved by vaccination against tissue-specific self-proteins that are retired from expression at immunogenic levels in normal tissues as we age, but are overexpressed in emerging tumors. alpha-Lactalbumin is an example of a retired self-protein because its expression in normal tissues is confined exclusively to the breast during late pregnancy and lactation, but is also expressed in the vast majority of human triple negative breast cancers (TNBC)-the most aggressive and lethal form of breast cancer and the predominant form that occurs in women at high genetic risk including those with mutated BRCA1 genes. In anticipation of upcoming clinical trials, here we provide preclinical data indicating that alpha-lactalbumin has the potential as a vaccine target for inducing safe and effective primary immunoprevention as well as immunotherapy against TNBC.
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