Journal
MATERIALS TODAY BIO
Volume 13, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtbio.2021.100191
Keywords
Virucidal materials; Virus inactivation; Virus clearance; Glass -based virucidal; Kaolinbased virucidal; Virus elimination
Funding
- Spanish National Research Council (CSIC) [202060E109]
- Comunidad Autonoma de Madrid [2017-T1/BIO-4992]
- Universidad Complutense de Madrid
- European Virus Archive GLOBAL (EVA-GLOBAL) project - European Union [871029]
- FPI fellowship - Universidad San Pablo CEU
- PFIS fellowship
- FEDER/FSE
- ISCIII
Ask authors/readers for more resources
Inorganic materials can be utilized to decontaminate various substances containing viral particles and provide effective disinfection and antiviral solutions. Novel soda-lime glass and kaolin containing metal nanoparticles show strong antiviral properties, demonstrating potent virucidal activity against multiple viruses.
Inorganic materials can provide a set of tools to decontaminate solid, liquid or air containing viral particles. The use of disinfectants can be limited or not practical in scenarios where continuous cleaning is not feasible. Physicochemical differences between viruses raise the need for effective formulations for all kind of viruses. In the present work we describe two types of antimicrobial inorganic materials: i) a novel soda-lime glass (G3), and ii) kaolin containing metals nanoparticles (Ag or CuO), as materials to disable virus infectivity. Strong antiviral properties can be observed in G3 glass, and kaolin-containing nanoparticle materials showing a reduction of viral infectivity close to 99% in the first 10 min of contact of vesicular stomatitis virus (VSV). A potent virucidal activity is also present in G3 and kaolin containing Ag or CuO nanoparticles against all kinds of viruses tested, reducing more than 99% the amount of HSV-1, Adenovirus, VSV, Influenza virus and SARS-CoV-2 exposed to them. Virucidal properties could be explained by a direct interaction of materials with viruses as well as inactivation by the presence of virucidal elements in the material lixiviates. Kaolin-based materials guarantee a controlled release of active nanoparticles with antiviral activity. Current coronavirus crisis highlights the need for new strategies to remove viruses from contaminated areas. We propose these low-cost inorganic materials as useful disinfecting antivirals in the actual or future pandemic threats.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available