Journal
JOURNAL OF CLINICAL MEDICINE
Volume 5, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/jcm5040041
Keywords
signaling transduction pathways; EMT; TGF-; SHH; WNT; modeling
Categories
Funding
- NIGMS-DMS joint mathematical biology program [DMS-1545771, DMS-1462049]
- PA Department of Health [SAP 4100062224]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [1462049] Funding Source: National Science Foundation
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Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor- (TGF-), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EMT. The functional roles of multi-signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In this review, we focused on three major signal transduction pathways that promote or regulate EMT in carcinoma. We discussed the network structures, and provided a brief overview of the current therapy strategies and drug development targeted to these three signal transduction pathways. Finally, we highlighted systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery.
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