Journal
JOURNAL OF CLINICAL MEDICINE
Volume 5, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/jcm5100087
Keywords
Sjogren's syndrome; B cells; marginal zone B cells
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Sjogren's syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.
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