Journal
GELS
Volume 8, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/gels8020124
Keywords
3D chitosan; gallic acid; 3D chitosan-gallic acid complexes; adsorption process; spectroscopic analyses; bioactivity
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Three-dimensional chitosan-gallic acid complexes were prepared by adsorbing gallic acid on three-dimensional chitosan structures. The complexes exhibited high antioxidant activity and antimicrobial capacity, making them suitable for nutraceutical, cosmeceutical, and pharmaceutical applications.
Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, up to 2015 mmol/kg at pH 4.0. The preservation of the redox state of GA released from 3D chitosan was confirmed by spectroscopic analyses. The antioxidant activity of 3D chitosan-GA complexes was assessed using the DPPH radical scavenging assay and was found to be dramatically higher than that of free chitosan. The mechanical property of 3D chitosan-GA complexes was also evaluated using a compression test. Finally, 3D chitosan-GA complexes showed a significant antimicrobial capacity against E. coli and S. aureus, selected, respectively, as a model strain for Gram-negative and Gram-positive bacteria. Our study demonstrated a new, simple, and eco-friendly approach to prepare functional chitosan-based complexes for nutraceutical, cosmeceutical, and pharmaceutical applications.
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