Journal
TRANSLATIONAL NEURODEGENERATION
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40035-016-0063-3
Keywords
Parkinson's disease; alpha-synucleinopathy; Inflammation; Biomarkers
Categories
Funding
- State Key Development Program for Basic Research of China [2011CB510000]
- National Natural Science Foundation of China [81271428, 81471292, U1503222, 81430021]
- keypoint Science Foundation of Guangdong of China [2015A030311021]
- technology project of Guangzhou [201604020152]
- assisting research project of science and technology for Xinjiang [201591160]
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Parkinson's disease (PD) is referring to the multi-systemic alpha-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration, especially in dopaminergic neurons. As a series of biomarkers, the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation. Furthermore, dopaminergic drugs change the biological characteristic of T lymphatic cells, affect the alpha-synuclein presentation pathway, and inhibit T lymphatic cells to release cytotoxicity in PD development. Taking together, the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction.
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