Journal
ACTA PHARMACEUTICA SINICA B
Volume 6, Issue 5, Pages 384-392Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2016.07.014
Keywords
Isoniazid; Metabolism; Hepatotoxicity; Anti-tuberculosis; N-Acetyltransferase 2; Amidase
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Funding
- NIDDK NIH HHS [R01 DK090305] Funding Source: Medline
- NIGMS NIH HHS [R01 GM087376, R01 GM118367] Funding Source: Medline
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Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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