Journal
ACTA PHARMACEUTICA SINICA B
Volume 6, Issue 4, Pages 268-286Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2016.05.013
Keywords
Brain targeting; Nanoparticles; Dual targeting; Intranasal delivery; Blood-brain barrier
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Funding
- National Natural Science Foundation of China [31571016, 81402866]
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Due to the ability of the blood brain bather (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the bathers to brain-targeted drug delivery are reviewed, including the BBB, blood brain tumor bather (BBTB), and nose-to-brain bather. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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