Journal
ACTA PHARMACEUTICA SINICA B
Volume 6, Issue 6, Pages 540-551Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2016.05.016
Keywords
Biological sample pretreatment; Solid phase micro-extraction; Column; rbulent flow hromatography; Restricted access material; Molecular imprinting solid phase extraction
Categories
Funding
- National Natural Science Foundation of China [81102499]
- Fundamental Research Funds for the Central Universities of Central South University
- Hunan Science and Technology Project [2011SK3261]
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Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography mass spectrometry (LC MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND
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