Journal
EBIOMEDICINE
Volume 12, Issue -, Pages 34-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ebiom.2016.09.017
Keywords
microRNA; Non-coding RNA; Cancer; Therapeutics; Clinical trials
Funding
- NIH/NCI [1UH2TR00943-01, 1 R01 CA182905-01]
- UT MD Anderson Cancer Center SPORE in Melanoma grant from NCI [P50 CA093459]
- Aim at Melanoma Foundation
- Miriam and Jim Mulva research funds
- UT MD Anderson Cancer Center Brain SPORE [2P50CA127001]
- Leukemia SPORE
- CLL Moonshot Flagship project
- Knowledge GAP MDACC grant
- Owens Foundation
- RGK Foundation
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MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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