Journal
AGING AND DISEASE
Volume -, Issue -, Pages -Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2022.0117
Keywords
acarbose; life span; gut microbiota
Categories
Funding
- Scientific Research Project of Jiangsu Commission of Health [M2021055]
- Jiangsu Scientific Research Project of Women's and Children's Health [F201741]
- Scientific Research Project of Wuxi Commission of Health [ZZ003]
- Wuxi scientific and technological development project [N20192024, N20191001, N2020X007]
- Translational medicine Research Program of Wuxi Translational Medicine Center [2020ZHYB08]
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This review discusses the effects of acarbose-regulated gut microbiota on factors influencing lifespan and suggests a novel theoretical basis for understanding the mechanisms by which acarbose extends the lifespan of mice.
Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested.
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