Journal
BIOENGINEERING-BASEL
Volume 9, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/bioengineering9010005
Keywords
anticancer; boron neutron capture therapy; nanoconjugate; neutron sensitizer; photodynamic therapy; photosensitizer; theranostic; UHPLC-HR MS; MS; preparative chromatography
Funding
- Russian Foundation for Basic Research [19-03-00255]
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In this study, a conjugate of chlorin e6 methyl ester with cyclen and dioxane, as well as nitrile derivatives of cobalt bis(dicarbollide), were synthesized to combine the neutron-capturing properties of boron nanoclusters and the photodynamic properties of natural chlorins. The purification conditions for compounds by HPLC were selected due to the presence of closely related impurities in natural compounds.
To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities.
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