Journal
EBIOMEDICINE
Volume 12, Issue -, Pages 178-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ebiom.2016.09.003
Keywords
Dengue; Plasmablasts; Memory B cells; Antibodies
Funding
- Agency for Science, Technology and Research A*STAR
- National Medical Research Council, Singapore [NMRC/TCR/005]
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Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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