The Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor

Article Biotechnology & Applied Microbiology

Bladder cancer-associated transcript 2 contributes to nephroblastoma progression

Jie Zhu et al.

Summary: The study demonstrated that BLACAT2 plays a role in nephroblastoma by interacting with miR-504-3p to regulate Wnt11, influencing tumor progression and therapeutic strategies.

JOURNAL OF GENE MEDICINE (2022)

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Review Genetics & Heredity

Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation

Ryan L. Kan et al.

Summary: Epigenetic modifications play a crucial role in gene expression regulation through modifications on genomic DNA, histones, and more recently, mRNA. These modifications, especially the common N6-methyladenosine (m6A) methylation, not only influence RNA stability and translation efficiency, but also interact with histone/DNA epigenetic mechanisms to specify transcriptional outputs and recruit chromatin modifiers. This review focuses on dissecting the feedback circuits orchestrated by m6A, which regulate histone modifications and the activity of regulatory RNAs, such as long noncoding RNA and chromosome-associated regulatory RNA. The evidence suggests that m6A acts as a versatile checkpoint linking different layers of gene regulation.

TRENDS IN GENETICS (2022)

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Article Urology & Nephrology

Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis

Jing Shen et al.

Summary: Elevated expression of MEG8 in Wilms' tumor cells is associated with malignant behavior, and it represses cell proliferation, migration, and invasion by targeting the miR-23a-3p/CRK axis.

UROLOGIA INTERNATIONALIS (2022)

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Review Multidisciplinary Sciences

Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov et al.

Summary: Tendinopathy is a common musculoskeletal disorder with no current cure. Research has identified novel targets like gene therapy and noncoding RNAs for enhancing tendon healing and repair. Recent advances in exosomes also show potential for tendinopathy treatment.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

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Article Oncology

LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation

Chen Chen et al.

Summary: The study identified a long noncoding RNA called LncCCLM that is downregulated in cervical cancer tissues and inhibits lymphangiogenesis and lymphatic metastasis in cervical cancer by regulating the degradation of IGF-1 mRNA. This suggests that LncCCLM may serve as a tumor suppressor and potential prognostic biomarker and therapeutic target for LN-metastatic cervical cancer.

CANCER LETTERS (2021)

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Article Cell Biology

Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2

Shibo Zhu et al.

Summary: Nephroblastoma, a pediatric kidney cancer, is associated with abnormal expression of lncRNA MYLK-AS1, which promotes cell proliferation and cycle distribution through the TCF7L2/CCNE1 signaling pathway. Silencing of MYLK-AS1 inhibits the tumorigenic ability of nephroblastoma cells in vivo, highlighting its potential as a biomarker for early detection and treatment.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Chemistry, Medicinal

The role of long noncoding RNA in lipid, cholesterol, and glucose metabolism and treatment of obesity syndrome

Qirong Lu et al.

Summary: lncRNA plays a crucial role in regulating abnormal metabolism in obesity syndromes, especially in lipid, cholesterol, and glucose metabolism. Food intake may induce abnormal expression of lncRNA associated with obesity syndromes. Some nanomolecules and natural extracts may target lncRNAs as a potential treatment for obesity syndromes.

MEDICINAL RESEARCH REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation and inhibits the proliferation of PASMCs caused by hypoxia

Yiying Li et al.

Summary: Recent evidence has shown that functional peptides encoded by lncRNAs have important roles in cell pathophysiological processes. This study reveals that the lnc-Rps4l-encoded peptide RPS4XL inhibits PASMCs proliferation under hypoxic conditions by interacting with RPS6 and inhibiting its phosphorylation. These findings provide potential targets for early diagnosis and treatment of hypoxic PH.

MOLECULAR THERAPY (2021)

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Review Cell Biology

Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function

Luca Ducoli et al.

Summary: The lymphatic vascular system plays a crucial role in tissue fluid transportation and its activation or impairment is linked to various diseases. Recent research has focused on understanding the mechanisms that control lymphangiogenesis and function, with a particular emphasis on the role of lymphatic endothelial cells in maintaining their vascular lineage identity and function.

DEVELOPMENTAL CELL (2021)

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Review Oncology

Unmet needs for relapsed or refractory Wilms tumour: Mapping the molecular features, exploring organoids and designing early phase trials - A collaborative SIOPRTSG, COG and ITCC session at the first SIOPE meeting

Jesper Brok et al.

Summary: Understanding the biology of Wilms tumour is crucial for developing innovative therapies and improving clinical outcomes, especially for high-risk subgroups with poorer prognoses. Challenges include small patient populations for early phase trials, genetic heterogeneity, and limited 'druggable' targets. Collaborative efforts are needed to advance research and improve enrolment rates in early phase trials for children with Wilms tumour.

EUROPEAN JOURNAL OF CANCER (2021)

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Review Oncology

Progress Update in Pediatric Renal Tumors

Juhi Jain et al.

Summary: Recent clinical trials have made significant improvements in the care of children with pediatric tumors, particularly in standardizing treatment for rare cancers such as bilateral Wilms tumor. While there have been improvements in event free and overall survival for many pediatric renal tumors in recent trials, there are still subsets of rarer cancers with poor outcomes that require new therapeutic strategies. Future trials aim to balance treatment toxicity and efficacy for those with good outcomes while exploring novel therapeutics for those with poor outcomes.

CURRENT ONCOLOGY REPORTS (2021)

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Review Genetics & Heredity

Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

Hao Li et al.

Summary: The adult mammalian kidney lacks stem cells for regeneration, unlike the embryonic kidney which contains lineage-specific stem cells giving rise to various kidney components; current research focuses on these embryonic progenitor cells which can shed light on the formation of Wilms tumor, a pediatric renal cancer.

GENES (2021)

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Review Biochemistry & Molecular Biology

EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer

Keila Torres et al.

Summary: Non-coding RNAs regulate gene expression by acting as competing endogenous RNA, with viral miRNAs competing with human miRNAs and shifting cellular process balance. EBV non-coding RNAs cause deregulation of human transcripts and contribute to tumor development.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Article Medicine, General & Internal

Wilms tumour

Filippo Spreafico et al.

Summary: Wilms tumour is the most common renal tumour in infants and young children, representing a paradigm of intersection between disrupted organogenesis and tumorigenesis. Understanding and targeting multiple genes and cellular control pathways active in Wilms tumour development is crucial for improving patient outcomes. Decades of research have optimized clinical care, but disparities in survival within and between countries persist and require commitment to change.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Oncology

Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma

Chen Zhong et al.

Summary: This study identified OXCT1-AS1 as a potential therapeutic target for glioma treatment, as high expression was associated with poor prognosis in GBM. OXCT1-AS1 inhibits glioma progression by acting as a ceRNA of miR-195 to enhance CDC25A expression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Cell Biology

Long noncoding RNAs: fine-tuners hidden in the cancer signaling network

Shanshan Zhao et al.

Summary: The advancement in sequencing technology has led to the identification of numerous long non-coding RNAs (lncRNAs) alongside coding genes, shedding light on their essential roles in cancer. Despite the limited understanding of the mechanisms of lncRNAs, their versatile roles in fine-tuning signaling pathways have piqued interest in the field of cancer research.

CELL DEATH DISCOVERY (2021)

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Article Oncology

Surgical Management of Wilms Tumor (Nephroblastoma) and Renal Cell Carcinoma in Children and Young Adults

Natalie M. Lopyan et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2021)

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Article Cell Biology

M2 macrophage-derived exosomal long non-coding RNA AGAP2-AS1 enhances radiotherapy immunity in lung cancer by reducing microRNA-296 and elevating NOTCH2

Fuquan Zhang et al.

Summary: The study revealed that AGAP2-AS1 was increased in radioresistant patients and lung cancer cells, while miR-296 showed a decreasing trend. Inhibiting AGAP2-AS1 helped promote the malignant phenotypes of radioresistant lung cancer cells. The results suggested that AGAP2-AS1 negatively regulated miR-296, thereby upregulating NOTCH2 and enhancing radiotherapy immunity in lung cancer.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia

Ganqian Zhu et al.

Summary: Mutations in the nucleophosmin (NPM1) gene lead to a specific gene expression program that causes acute myeloid leukemia. The activation of a long non-coding RNA associated with the HOXB locus by mutant NPM1 is crucial for its oncogenic transcriptional program and leukemia development.

NATURE COMMUNICATIONS (2021)

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Review Cell Biology

Long noncoding RNA-dependent methylation of nonhistone proteins

Salinee Jantrapirom et al.

Summary: Long noncoding RNAs (lncRNAs) have emerged as regulators of posttranslational modifications on nonhistone proteins, acting as scaffolds to bring methyltransferases (MTases) and target proteins in close proximity. These lncRNAs utilize MTases like EZH2, protein arginine-MTase 1/4/5, and SMYD2 to modulate the stability and compartmentalization of nonhistone proteins involved in cell signaling, gene expression, and RNA processing. Additionally, lncRNAs can indirectly affect nonhistone protein methylation by regulating MTases transcriptionally or posttranscriptionally. The networking of lncRNAs/MTases/nonhistone proteins appears to be relevant in carcinogenesis and neurological disorders.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2021)

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Review Immunology

Long Noncoding RNA: Regulatory Mechanisms and Therapeutic Potential in Sepsis

Wei Wang et al.

Summary: Long noncoding RNAs (lncRNAs) play dual roles in promoting and inhibiting immune functions in sepsis, contributing to the regulation of sepsis progression. Studies have shown that lncRNAs are also involved in sepsis-induced organ dysfunctions, suggesting their potential as biomarkers and treatment targets in sepsis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Expression and mechanism of exosome-mediated A FOXM1 related long noncoding RNA in gastric cancer

Yan Zhang et al.

Summary: The study revealed that FRLnc1 in exosomes plays a role in promoting the growth and metastasis of gastric cancer by enhancing cell proliferation and migration. This suggests that FRLnc1 may serve as a potential biomarker for the diagnosis and treatment of gastric cancer, providing a new avenue for therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1

Jing Luo et al.

Summary: The study identified GAS6-AS1 as a novel tumor suppressor in LUAD by inhibiting glucose metabolism reprogramming through regulation of GLUT1, offering potential prognostic and therapeutic implications for patients.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Xingyue He et al.

Summary: The study revealed that XIST lncRNA levels were elevated in Wilms tumor (WT) patients and were associated with TNM staging and shorter survival time. XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting its involvement in the miR-194-5p/YAP pathway. XIST was found to have oncogenic effects in WT, acting as a competitive endogenous RNA that regulates the miR-194-5p/YAP pathway.

CANCER MANAGEMENT AND RESEARCH (2021)

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Review Oncology

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms' Tumors

Andrea Pelosi et al.

Summary: Neuroblastoma and Wilms' tumor are common childhood solid extracranial tumors, and the challenge lies in developing new therapeutic strategies to reduce adverse effects. Studying the immune environment can identify new therapeutic targets, such as the immunosuppressive activity of tumor cells on natural killer cells and monocytes. Natural killer cells play a crucial role in controlling cancer, but tumor cells can inhibit their function through various mechanisms, including the establishment of an immunosuppressive tumor microenvironment.

CANCERS (2021)

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Review Oncology

Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

Suaidah Ramli et al.

Summary: Long noncoding RNA UCA1 is overexpressed in gastrointestinal cancers and plays key roles in cancer progression and chemoresistance by regulating cell proliferation, invasion, migration, and interacting with various molecules, particularly microRNAs and signaling pathways. Its implications in different GI cancers indicate its potential as a therapeutic target, diagnostic marker, and prognostic indicator for patients with GI cancer.

JOURNAL OF ONCOLOGY (2021)

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Article Pediatrics

A long non-coding RNAs expression signature to improve prognostic prediction of Wilms tumor in children

Hongyan Zhao et al.

Summary: This study identified key lncRNAs associated with prognosis in children with Wilms tumor and established a genomic-clinicopathologic nomogram for survival prediction. The combined model and risk score model showed higher predictive accuracy, revealing potential molecular mechanisms and immune microenvironment changes that affect Wilms tumor prognosis.

TRANSLATIONAL PEDIATRICS (2021)

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Review Oncology

LINC00261: a burgeoning long noncoding RNA related to cancer

Menggang Zhang et al.

Summary: LINC00261, a recently discovered long intergenic non-protein coding RNA, is over-expressed in various human malignancies and functions as a tumor suppressor by regulating biological processes in cancer cells. Its up-regulation is closely correlated with favorable prognoses and clinical characteristics. This lncRNA shows promising prospects as both a biomarker and therapeutic target in tumor development.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

ELF3-AS1 contributes to gastric cancer progression by binding to hnRNPK and induces thrombocytosis in peripheral blood

Shubin Song et al.

Summary: Numerous studies have reported that various long noncoding RNAs (lncRNAs) can promote the proliferation, invasion, and migration of tumor cells. Here, the researchers investigated the effect of lncRNA ELF3-AS1 on gastric cancer (GC) cells and explored the exact mechanisms. High expression of ELF3-AS1 in GC tissues was associated with poor prognosis, and knockdown of ELF3-AS1 inhibited cell proliferation, migration, and promoted apoptosis. Mechanistic investigations revealed that ELF3-AS1 may regulate downstream target genes by binding with RNA-binding protein hnRNPK. Additionally, high ELF3-AS1 expression was found to be associated with thrombocytosis in GC.

CANCER SCIENCE (2021)

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Review Cell Biology

The Integrator complex at the crossroad of coding and noncoding RNA

Nina Kirstein et al.

Summary: The Integrator complex plays a crucial role in regulating transcription processes, including processing of noncoding RNAs and release of RNA polymerase II, with implications in cellular development and signaling response. Alterations in Integrator subunits have been linked to neurodevelopmental diseases and cancer, underscoring its significance in disease progression and genomic complexity.

CURRENT OPINION IN CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

The Emerging Role of Thymopoietin-Antisense RNA 1 as Long Noncoding RNA in the Pathogenesis of Human Cancers

Qiuxian Zheng et al.

Summary: TMPO-AS1 exhibits abnormally high expression levels in various cancers, acting as a ceRNA to inhibit miRNA expression and activate downstream oncogenes, playing a pivotal role in tumorigenesis and progression.

DNA AND CELL BIOLOGY (2021)

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Review Oncology

Wilms tumour surveillance in at-risk children: Literature review and recommendations from the SIOP-Europe Host Genome Working Group and SIOP Renal Tumour Study Group

Janna A. Hol et al.

Summary: The updated Wilms tumour surveillance guidelines have been released for clinical geneticists, pediatricians, pediatric oncologists, and radiologists caring for children at risk of WT. These guidelines stress the importance of registering all patients with cancer predisposition syndromes in order to improve future tumor risk estimation and surveillance programs.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Cell Biology

LINC00511 promotes gastric cancer progression by regulating SOX4 and epigenetically repressing PTEN to activate PI3K/AKT pathway

Qianwei Wang et al.

Summary: This study found that LINC00511 is highly expressed in gastric cancer cells, promoting cell proliferation, migration, stemness, and EMT while inhibiting apoptosis. LINC00511 epigenetically represses PTEN to activate the PI3K/AKT pathway by recruiting EZH2. Additionally, SOX4 activates the transcription of LINC00511, which in turn sponges miR-195-5p to elevate SOX4 expression. This ceRNA mechanism facilitates gastric cancer progression.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Oncology

Impact of the First Generation of Children's Oncology Group Clinical Trials on Clinical Practice for Wilms Tumor

Jeffrey S. Dome et al.

Summary: Advancements in surgery, radiation therapy, and chemotherapy have increased the survival rate of Wilms tumor patients, but a significant proportion still face challenges in achieving event-free survival. The first-generation COG renal tumor trials focused on personalized treatment strategies for different prognostic subgroups to improve outcomes.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

Xudong Huang et al.

Summary: LINC00842 plays a role in promoting the malignancy of pancreatic ductal adenocarcinoma by regulating the acetylation status of PGC-1 alpha, leading to metabolic reprogramming in cancer cells.

NATURE COMMUNICATIONS (2021)

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Review Physiology

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Xinghui Sun et al.

Summary: Cellular senescence is a stable form of cell cycle arrest in response to various stressors and plays a role in aging. This review discusses the recent advances in understanding cellular senescence, including mechanisms, regulation, and challenges in endothelial cell aging, offering new insights for managing cardiovascular disease risk.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Oncology

High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity

Susanne G. Kidd et al.

Summary: In primary prostate cancer, high expression of SCHLAP1 serves as a robust prognostic biomarker for predicting biochemical recurrence and is associated with adverse clinicopathological characteristics. The heterogeneity of SCHLAP1 expression emphasizes the importance of analyzing multiple samples for determination of a patient's SCHLAP1 status.

NEOPLASIA (2021)

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Review Oncology

Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Alissa Groenendijk et al.

Summary: In high-income countries, 90% of children with Wilms tumors survive, but 15% may experience tumor recurrence. Identifying patients at risk of recurrence is crucial for adjusting treatment. Factors influencing recurrence range from patient, tumor, and treatment characteristics to geographic and socioeconomic factors. Further research on biological markers, like genetic alterations, is needed to better identify patients at risk of tumor recurrence.

CANCERS (2021)

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Review Mathematical & Computational Biology

Web tools to perform long non-coding RNAs analysis in oncology research

Shixing Gu et al.

Summary: Long non-coding RNAs play crucial roles in biogenesis, particularly in cancer. Understanding the specific mechanisms and tissue-specific expression patterns of lncRNAs is important for identifying diagnostic/prognostic markers or potential therapeutic targets. Although bioinformatics analysis is the first step, researchers may face time wastage in selecting appropriate web tools due to their unique and common features.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2021)

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Article Oncology

LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients

Haihua Tian et al.

Summary: The upregulation of the antisense lncRNA DPP10-AS1 promotes malignant processes in lung cancer by regulating its sense gene DPP10 epigenetically. DPP10-AS1 could potentially serve as a candidate prognostic biomarker and a therapeutic target in lung cancer due to its effects on tumor growth and apoptosis suppression.

CANCER BIOLOGY & MEDICINE (2021)

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Article Medicine, Research & Experimental

Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2

Xiaohong Xiang et al.

Summary: This study identified PINT87aa as a novel biomarker and key regulator of cellular senescence in HCC, highlighting its potential as a therapeutic target for HCC.

THERANOSTICS (2021)

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Review Biochemical Research Methods

Decoding competing endogenous RNA networks for cancer biomarker discovery

Xin Qi et al.

BRIEFINGS IN BIOINFORMATICS (2020)

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Review Biochemistry & Molecular Biology

Adaptor proteins in long noncoding RNA biology

Emily Dangelmaier et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2020)

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Article Biochemistry & Molecular Biology

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

Christoph Knappich et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Cell Biology

LINC00667 promotes Wilms' tumor metastasis and stemness by sponging miR-200b/c/429 family to regulate IKK-β

Pei Liu et al.

CELL BIOLOGY INTERNATIONAL (2020)

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Review Cardiac & Cardiovascular Systems

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

Cheng-Kai Huang et al.

CIRCULATION RESEARCH (2020)

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Review Cell Biology

Long Noncoding RNA in Myeloid and Lymphoid Cell Differentiation, Polarization and Function

Imran Ahmad et al.

CELLS (2020)

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Article Gastroenterology & Hepatology

Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation

Yanan Pang et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Oncology

Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor

Zifeng Liu et al.

ONCOLOGY LETTERS (2020)

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Review Biochemistry & Molecular Biology

Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology

Xiao Yang et al.

MOLECULAR CANCER (2020)

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Review Oncology

Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations

Xiao-Zhen Zhang et al.

CANCERS (2020)

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Article Oncology

Multi-Omics Integration Reveals a Competitive Endogenous RNAs Network for the Identification of Progression Biomarkers and the Stratification of Patients Diagnosed With Nephroblastoma

Jingbo Wang et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Long noncoding RNA loss in immune suppression in cancer

Qingsong Hu et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Oncology

Paediatric metanephric tumours: a clinicopathological and molecular characterisation

Dominique V. C. de Jel et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Therapeutic potential of extracellularvesicle-associatedlongnoncoding RNA

Louis J. Born et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Mechanisms of Long Noncoding RNA Nuclear Retention

Chun-Jie Guo et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

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Review Biochemistry & Molecular Biology

An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer

Roya Amirinejad et al.

CELL AND BIOSCIENCE (2020)

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Review Genetics & Heredity

Long noncoding RNA functionality in imprinted domain regulation

William A. MacDonald et al.

PLOS GENETICS (2020)

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Article Genetics & Heredity

FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway

Cheng-Cao Sun et al.

GENOME MEDICINE (2020)

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Review Oncology

Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer

Natalia Landeros et al.

CANCERS (2020)

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Review Andrology

Wilms tumor: a review of current surgical controversies

Karen Milford et al.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2020)

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Review Oncology

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Yalu Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Oncology

The functional role of long noncoding RNA in resistance to anticancer treatment

Yidi Qu et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Mitochondrial noncoding RNA-regulatory network in cardiovascular disease

Amela Jusic et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Review Urology & Nephrology

The genetic changes of Wilms tumour

Taryn Dora Treger et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Review Cell Biology

The cellular landscape of mid-size noncoding RNA

Vincent Boivin et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2019)

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Article Cell Biology

Molecular anatomy of the architectural NEAT1 noncoding RNA: The domains, interactors, and biogenesis pathway required to build phase-separated nuclear paraspeckles

Tetsuro Hirose et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2019)

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Review Oncology

Noncoding RNA transcription at enhancers and genome folding in cancer

Takeshi Isoda et al.

CANCER SCIENCE (2019)

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Article Oncology

Patient selection and technical aspects for laparoscopic nephrectomy in Wilms tumor

Andreas Schmidt et al.

SURGICAL ONCOLOGY-OXFORD (2019)

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Article Biotechnology & Applied Microbiology

Silencing long non-coding RNA SNHG6 restrains proliferation, migration and invasion of Wilms' tumour cell lines by regulating miR-15a

Limin Su et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Review Oncology

Origins of DNA methylation defects in Wilms tumors

Zahra Anvar et al.

CANCER LETTERS (2019)

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Review Urology & Nephrology

The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management

Varune Rohan Ramnarine et al.

EUROPEAN UROLOGY (2019)

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Review Genetics & Heredity

Non-Coding RNAs in Pediatric Solid Tumors

Christopher M. Smith et al.

FRONTIERS IN GENETICS (2019)

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Review Cell Biology

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

Raheleh Amirkhah et al.

CELLS (2019)

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Review Cell Biology

Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

Wenguang Chang et al.

CELLS (2019)

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Editorial Material Pharmacology & Pharmacy

Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

Baitang Ning et al.

BIOCHEMICAL PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

The role of long noncoding RNA in major human disease

Xiaoli Zhang et al.

BIOORGANIC CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer

Liye Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

A three long non-coding RNA signature to improve survival prediction in patients with Wilms' tumor

Ping Ren et al.

ONCOLOGY LETTERS (2019)

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Review Oncology

Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience

Filippo Spreafico et al.

CANCER AND METASTASIS REVIEWS (2019)

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Review Oncology

Novel therapy for pediatric and adolescent kidney cancer

Amy L. Walz et al.

CANCER AND METASTASIS REVIEWS (2019)

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Review Oncology

Long noncoding RNA expression profiling in cancer: Challenges and opportunities

Lucia Lorenzi et al.

GENES CHROMOSOMES & CANCER (2019)

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Review Cell Biology

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

Rasoul Abdollahzadeh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Cell & Tissue Engineering

Long Noncoding RNA: Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells

Jian Zhu et al.

CURRENT STEM CELL RESEARCH & THERAPY (2019)

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Article Cell Biology

Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression

Patrick McDonel et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

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Article Microbiology

Noncoding RNA

E. Desgranges et al.

MICROBIOLOGY SPECTRUM (2019)

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Article Physiology

Long Noncoding RNA: Genomics and Relevance to Physiology

Yiwei Kong et al.

COMPREHENSIVE PHYSIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

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