Journal
EBIOMEDICINE
Volume 9, Issue -, Pages 97-109Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2016.05.027
Keywords
NKX6.3; Wnt/beta-catenin; Rho-GTPase; EMT; Gastric cancer
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2015R1A2A2A05001023, 2014R1A1A2058693]
- National Research Foundation of Korea [2014R1A1A2058693, 2015R1A2A2A05001023] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/beta-catenin and Rho-GTPase signaling pathways are known to play essential roles inmalignant transformation and progression of various tumors, including gastric cancer. Here, we identify that NKX6 transcription factor, locus 3 (NKX6.3) binds directly to specific promoter regions of Wnt/beta-catenin and Rho-GTPase pathway-related genes, resulting in inhibition of cancer cell migration and invasion. Additionally, we find that the expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt/beta-catenin and Rho-GTPase pathway-related genes in clinical samples. These results suggest that NKX6.3 prevents EMT and cell migration, implying that NKX6.3 inactivation might be one of the key mechanisms of gastric cancer cell invasion and metastasis. (C) 2016 The Authors. Published by Elsevier B.V.
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