Journal
SCIENCE ADVANCES
Volume 2, Issue 10, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.1600567
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Funding
- U.K. Engineering and Physical Sciences Research Council (EPSRC) Leadership Fellowship [EP/H005374/1]
- EPSRC Programme Grant [EP/I001514/1]
- Global Research Laboratory Program of the National Research Foundation of Korea [K20904000004-11A0500-00410]
- EPSRC [EP/I001514/1, EP/H005374/1, EP/F010834/1] Funding Source: UKRI
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Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach uses a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated. The potential of this method is demonstrated by creating droplets with enhanced stability, where this is achieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. The interface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible, supporting in vitro protein expression in their interiors. This general strategy will find widespread application in advancing emulsion properties for use in chemistry, biology, materials, and medicine.
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