Journal
KIDNEY360
Volume 3, Issue 2, Pages 337-340Publisher
AMER SOC NEPHROLOGY
DOI: 10.34067/KID.0007702021
Keywords
chronic kidney disease; biomarkers; brain; kidney tubules; neuroimaging
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Funding
- National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) Ruth L. Kirschstein National Research Service Award [5F32DK127590-02]
- NIDDK mid-career mentoring award [K24DK110427]
- NIDDK [R01DK098234, R01AG055606, R01 DK092241]
- Alzheimer's Association
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This study is the first evaluation of the relationship between kidney tubule biomarkers and brain imaging by MRI in patients with CKD, and it found that urine biomarker concentrations were not associated with brain MRI measures.
Key Points Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures. Higher eGFR was associated with lower total brain cerebral blood flow. This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.
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