4.6 Article

Wave-shaped microfluidic chip assisted point-of-care testing for accurate and rapid diagnosis of infections

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels at initial hospital presentation in COVID-19 patients are associated with an increased risk of venous thromboembolism, acute kidney injury, critical illness, and mortality. There is a dose-response relationship between CRP concentration and adverse outcomes, with patients with high levels of both CRP and D-dimer showing the greatest risk of adverse outcomes. Systemic inflammation, as measured by CRP, plays a significant role in predicting clinical outcomes in COVID-19.

EUROPEAN HEART JOURNAL (2021)

Article Chemistry, Multidisciplinary

Graphene Enabled Low-Noise Surface Chemistry for Multiplexed Sepsis Biomarker Detection in Whole Blood

Uros Zupancic et al.

Summary: The study introduces an EC sensor platform with a nanocomposite coating that enables simultaneous detection of multiple sepsis biomarkers, showing a good correlation with clinical samples. This platform offers a sensitive and specific tool for clinical point-of-care diagnostics.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Point-of-Care Testing for Multiple Cardiac Markers Based on a Snail-Shaped Microfluidic Chip

Binfeng Yin et al.

Summary: The study presents a snail-shaped microfluidic chip (SMC) for multiplex detection of cardiac markers with high sensitivity and short detection time. The SMC, consisting of a sandwich structure, can detect cTnI, CK-MB, and Myo at low concentrations, making it a promising platform for simultaneous determination of multianalytes with potential application in POCT.

FRONTIERS IN CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples

Sanjay S. Timilsina et al.

Summary: The team developed an efficient antifouling coating for multiplexed EC sensors, addressing the sensitivity and selectivity loss caused by biological samples, and made significant progress.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Review Biotechnology & Applied Microbiology

Aptamer-based biosensors for the diagnosis of sepsis

Lubin Liu et al.

Summary: Sepsis is a serious and growing global problem, with early detection of pathogens and biomarkers being crucial in selecting appropriate antibiotics. Aptamer-based biosensors are emerging as a reasonable strategy for sepsis diagnosis due to their accessibility, rapidity, and stability.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

A Microfluidic Chip-Based MRS Immunosensor for Biomarker Detection via Enzyme-Mediated Nanoparticle Assembly

Binfeng Yin et al.

Summary: A novel microfluidic chip-based magnetic relaxation switching (MRS) immunosensor using enzyme-mediated nanoparticles was developed to simplify operation and amplify signals, achieving a satisfactory limit of detection for alpha-fetoprotein (AFP) in real samples, outperforming conventional ELISA.

FRONTIERS IN CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Point-of-Care Immunoassays with Tunable Detection Range for Detecting Infection in Intensive Care Unit

Lei Mou et al.

Summary: The authors developed an automatic, multiplexed point-of-care immunoassay for detecting multiple biomarkers in serum samples. They proposed new diagnostic indicators mScore and mScorePlus which showed advantages in improving diagnostic accuracy and providing more analytical information. Integrating multiple markers into one parameter is an effective method for analytical applications.

CCS CHEMISTRY (2021)

Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels upon hospital admission in COVID-19 patients are associated with increased risks of VTE, AKI, critical illness, and mortality, suggesting a crucial role of systemic inflammation in the clinical course of COVID-19.

EUROPEAN HEART JOURNAL (2021)

Review Chemistry, Multidisciplinary

Barcoded point-of-care bioassays

Mingzhu Yang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Chemistry, Multidisciplinary

Integrated Biosensor for Rapid and Point-of-Care-Sepsis Diagnosis

Jouha Min et al.

ACS NANO (2018)

Article Chemistry, Analytical

Effective mixing in a short serpentine split-and-recombination micromixer

Wasim Raza et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Article Chemistry, Analytical

Recent advances and applications of micromixers

Chia-Yen Lee et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Review Rheumatology

The role of IL-6 in host defence against infections: immunobiology and clinical implications

Stefan Rose-John et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Review Immunology

The immunopathology of sepsis and potential therapeutic targets

Tom van der Poll et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biotechnology & Applied Microbiology

Bioanalytical advances in assays for C-reactive protein

Sandeep Kumar Vashist et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Immunology

The immune system's role in sepsis progression, resolution, and long-term outcome

Matthew J. Delano et al.

IMMUNOLOGICAL REVIEWS (2016)

Review Biochemical Research Methods

3D printed microfluidic devices: enablers and barriers

Sidra Waheed et al.

LAB ON A CHIP (2016)

Review Medicine, General & Internal

Sepsis: pathophysiology and clinical management

Jeffrey E. Gotts et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Review Medicine, General & Internal

Sepsis: pathophysiology and clinical management

Jeffrey E. Gotts et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Review Medicine, General & Internal

Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease

Donald M. Lloyd-Jones et al.

ANNALS OF INTERNAL MEDICINE (2006)

Article Medicine, General & Internal

C-reactive protein and the risk of incident colorectal cancer

TP Erlinger et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

Article Medicine, General & Internal

A randomized trial of aspirin to prevent colorectal adenomas

JA Baron et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)